To know more about Ginsenoside Rg3, the purer the ginsenoside composition, or the better the variety?

There is no doubt that ginsenoside can resist cancer. This is the truth after a large number of scientific demonstration and clinical trials, as well as the praise of millions of cancer patients. Many patients and their families learned about the artifact of "ginsenoside" through various channels, so they can't wait to buy it to take, so as to get rid of cancer as soon as possible. But the problem is, so many kinds of ginsenoside products, so many kinds of ginsenoside ingredients, some say that their ingredients are single, some say that their ingredients are diverse, but which one has the best anti-cancer effect? Is it safest to take?

Let's grill the ginsenosides to see whether the purer the ingredients, the better or the more.

It is said that anti-cancer should be "stable", "accurate" and "ruthless". Cancer patients are so fragile that they can't stand the second destruction. The most important thing is to keep the anti-cancer drug "stable"! Stability is safety! So, ask a question: is ginsenoside safe against cancer?

The standard answer is: the absolute safety of Ginsenoside Rg3 traditional Chinese medicine monomer; the absolute safety of ginsenoside Rh2 traditional Chinese medicine monomer; the safety of ginsenoside RK2, Rg5, RK1, rk3, Rh1, rh3, RH4 and oppd can not be verified!

No one can succeed at will, and no drug can be put on the market at will! I think that in addition to the names of ingredients and "√" "XX", the rest of the tables are not clear. Let's popularize the science for you. Anti cancer drugs need to go through those processes from research and development to marketing.

The process is divided into four parts: "preclinical research", "clinical trial approval", "clinical trial" and "new drug marketing approval, post marketing research and re approval". We said it one by one with questions.

What is clinical trial? The word "clinical trial" is often heard, but what exactly is it? To put it bluntly, it's about experimenting with people. We should do what we can when we do a trial with people, so we need to have two steps of "preclinical research" and "clinical trial approval" to guarantee the "clinical trial".

So here comes the question: what is preclinical research?

Taking Ginsenoside Rg3 as an example:

First of all, research and development should be carried out to find ginsenoside in red ginseng and confirm its anticancer effect, that is, the discovery and confirmation of drug targets. After the confirmation, Rg3, the effective anticancer core component in ginsenoside, was found out, that is, the compounds were screened and synthesized. It is not enough to find out. Pharmacists need to carry out a series of optimization on Rg3, that is, the verification and optimization of active compounds. After that, the research and development phase will be completed (about 3 years).

Then real preclinical trials began - pharmacology research, toxicology research, preparation development (not much to say, Baidu). In order to prove the preliminary safety of Ginsenoside Rg3, animal experiments (mice, dogs, monkeys) were carried out in vitro. After the completion of the above and the approval of CFDA (State Food and Drug Administration), the pre clinical trial is considered to be successful (about 4 years), and can enter the clinical trial stage.

The pile marked with "X" in the above table is blank at the corresponding stage and fails to pass the CFDA audit. Patients and their families should be aware of it.

What is the role of each phase of clinical trials?

Phase I clinical trial: after all, cells and animals in vitro are not human beings, and it's not safe for anyone to use them. But it doesn't matter. The role of phase I clinical trial is to prove the safety - to find 20-100 healthy people to test the safety of drugs, and to prove the safety of drugs after passing the trial, so simple and objective, if it can't pass, it can be stopped. (those who draw "X" Not much)

Phase II clinical trial: after testing safety in healthy people, the next step is to test its effectiveness in cancer patients. You can't patronize safety, don't you think about efficacy? The key to targeted treatment of cancer is not "accurate"! "Quasi" is effectiveness. Otherwise, what's the difference with eating sugar beans? The role of phase II clinical trial is to prove its effectiveness - find 100-300 patients to test the effectiveness of the drug. If it passes the trial, it will prove that it is effective for anti-cancer. If it doesn't pass, it's no different from tangdou, where to stay cool and where to stay. Cancer patients don't have time to have fun with you. (the one with "√" in phase I clinical trial and "×" in phase II clinical trial Attention)

Phase III clinical trial: effective, effective to what extent, we have to find out, the efficacy is not "cruel" stand instability, how to prove "cruel"? This is the role of phase III clinical trials: to further verify the therapeutic effect and safety of drugs on target patients - to find 300-5000 patients and strictly verify the efficacy and safety of drugs, this stage often lasts for many years.

If the feedback result of any step of the above process is not good, a drug project may be stopped or cancelled directly. There are fewer and fewer new drugs that can be successfully marketed through all three phase clinical trials, in part because it is more and more difficult to develop new drugs with better comprehensive evaluation than existing drugs on the market. And a drug from research to the end of phase III clinical trials is a costly process, public data shows that the average cost of a new drug is one billion dollars.

Phase IV clinical trial: after successfully completing phase III clinical trial, new drug application can be submitted to the drug regulatory department